Journal: Frontiers in Oncology

Article Title: Grape seed proanthocyanidins improve lymphatic drainage and blood perfusion in secondary lymphedema models

doi: 10.3389/fonc.2025.1553090

Figure Lengend Snippet: The tail diameter ratio of the control and medication group during the follow-up period, and photos of tails in the 8th week. From the 1st week, daily injections of saline (control group) and GSPE solution (medication group) were administered for 2 weeks. Significance was assessed by using Student’s t-test with p-value. Adjusted significance levels are denoted as p < 0.05 (*), p < 0.01 (**), p < 0.005 (***), and p < 0.001 (****).

Article Snippet: In the experimental group (medication group), GSPE compound powder (HL189) provided by Hanlim Pharmaceutical company in the Republic of Korea was mixed in saline and administered intraperitoneally at a dose of 100 mg/kg, adjusted to each animal’s weight, with a total volume of 1 ml per injection.

Techniques: Control, Saline

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on the growth performance of rabbits.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques:

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on slaughter performance of meat rabbits.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques:

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on organ coefficients in meat rabbits.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques:

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on serum biochemical indicators in meat rabbits.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques:

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on liver morphology of weaned rabbits challenged with hydrogen peroxide (H 2 O 2 ). Control, rabbits fed the basal diet; H 2 O 2 , rabbits fed the basal diet and given intraperitoneal injection of H 2 O 2 ; H 2 O 2 +GSPE, rabbits fed the basal diet supplemented with 400 mg/kg and given intraperitoneal injection of H 2 O 2 .

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques: Control, Injection

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on liver oxidative capacity of weaned rabbits challenged with hydrogen peroxide (H 2 O 2 ). ( A ) malondialdehyde; ( B ) superoxide dismutase; ( C ) catalase; ( D ) glutathione. Control, rabbits fed the basal diet; H 2 O 2 , rabbits fed the basal diet and given intraperitoneal injection of H 2 O 2 ; H 2 O 2 +GSPE, rabbits fed the basal diet supplemented with 400 mg/kg and given intraperitoneal injection of H 2 O 2 . a,b,c Means with different lowercase letters differ significantly among treatments ( p < 0.05). n = 8.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques: Control, Injection

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on small intestinal morphometric measurements of weaned rabbits challenged with hydrogen peroxide (H 2 O 2 ). ( A ) Villus height; ( B ) crypt depth; ( C ) villus height/crypt depth. Control, rabbits fed the basal diet; H 2 O 2 , rabbits fed the basal diet and given intraperitoneal injection of H 2 O 2 ; H 2 O 2 +GSPE, rabbits fed the basal diet supplemented with 400 mg/kg and given intraperitoneal injection of H 2 O 2 . a,b Means with different lowercase letters differ significantly among treatments ( p < 0.05). n = 8.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques: Control, Injection

Journal: Animals : an Open Access Journal from MDPI

Article Title: Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits

doi: 10.3390/ani15030327

Figure Lengend Snippet: Effects of dietary supplementation with grape seed proanthocyanidin extract (GSPE) on small intestinal oxidative capacity of weaned rabbits challenged with hydrogen peroxide (H 2 O 2 ). ( A ) MDA, malondialdehyde; ( B ) SOD, superoxide dismutase;( C ) CAT, catalase; ( D ) GSH, glutathione. Control, rabbits fed the basal diet; H 2 O 2 , rabbits fed the basal diet and given intraperitoneal injection of H 2 O 2 ; H 2 O 2 +GSPE, rabbits fed the basal diet supplemented with 400 mg/kg and given intraperitoneal injection of H 2 O 2 . a,b,c Means with different lowercase letters differ significantly among treatments ( p < 0.05). n = 8.

Article Snippet: The basal diet ( ) used in the trials was formulated in line with the nutrient requirements recommended by the Nutrition Requirements of Meat Rabbits (NY/T 4049-2021, Ministry of Agriculture of China), and the GSPE (CAS 4852-22-6, purity ≥ 95%) was purchased from Solarbio Science & Technology Co., Ltd. (Beijing, China).

Techniques: Control, Injection